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KMID : 0369819910210040201
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Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 4 p.201 ~ p.213
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Mechanisms of Multiple Peak Phenomenon in the Plasma Profile of Drugs Following Oral Administration
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심창구/Shim CK
이혜원/Lee HW
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Abstract
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There are many drugs reproted to show unusual pharmacokinetic behavior by producing a significant secondary peak in the plasma concentration-time curve after oral administration. The drugs are ranitidine, cimetidine, acetaminophen, aspirin, furosemide, bumetanide, piretanide, veralipride, sobrerol, penicillamine and doxycycline etc. Enterohepatic circulation-, two absorption site-, biphasic gastric emptying-, tissue deposition- and multi-fraction absorption theories have been suggested for the mechanisms of this phenomenon. Here, the theories were reviewed and critisized for their validity as a possible mechanism of the multiple peak phenomenon.
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KEYWORD
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multiple peak, ranitidine, acetaminophen, enterohepatic circulation, biphasic gastric emptying
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